নির্দেশনা

Eluxadoline is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).

উপাদান

ফার্মাকোলজি

Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxadoline works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.

মাত্রা ও সেবনবিধি

The recommended dose is 75 mg tablet taken orally twice daily with food. Patients who develop severe constipation for more than 4 days have to discontinue the drug. If a dose is missed, patient should take the next dose at the regular time and avoid taking two doses at a time. Pediatric Use : Safety and effectiveness in pediatric patients have not been established. Hepatic Impairment : It is contraindicated in patients with severe hepatic impairment.

প্রতিনির্দেশনা

Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.

পার্শ্ব প্রতিক্রিয়া

Most common adverse reactions are constipation, nausea and abdominal pain.

গর্ভাবস্থায় ও স্তন্যদানকালে

Pregnancy: Not established. Lactation: Not established.

সতর্কতা

Sphincter of Oddi spasm and Pancreatitis. Patients who should be monitored closely- without a gallbladder with new or worsening abdominal pain with nausea and vomiting with acute biliary pain with liver or pancreatic enzyme elevation

থেরাপিউটিক ক্লাস

Carboxylic acids and derivatives, Prokinetic drugs

সংরক্ষণ

Store in a cool & dry place, protect from light. Keep out of the reach of children.