নির্দেশনা
5HTP is indicated in- Anxiety Insomnia Depression Chronic headache Fibromyalgia
Composition
- 5-Hydroxytryptophan (Griffonia simplicifolia) 100 mg
- powdered valerian extract (Valeriana officinalis) 100 mg
ফার্মাকোলজি
5-Hydroxytryptophan (5HTP) is decarboxylated "in vivo" to yield serotonin, a neuro-hormonal transmitter released by neurons in the brain, spinal cord and symphatetic ganglia. Its seed contains active drug 5-hydroxytryptophan (5HTP). 5HTP is an aromatic amino acid naturally produced by the body from the essential amino acid L-tryptophan. Produced commercially by extraction from the seeds of the African plant Griffonia simplicifolia. Valerian extract is effective in treating mild-to-moderate sleeping disorders without adverse effects on REM sleep and without significant hangover effects. Valerian has a sedative-hypnotics, anxiolytic, antidepressant, anticonvulsant and antispasmodic effects. 5HTP acts primarily by within the centralesing levels of serotonin nervous system. Other neurotransmitters and CNS chemicals, such as melatonin, dopamine, norepinephrine, and beta endorphin have also been shown to increase following oral administration of 5HTP. Valepotriate binds to dopamine receptors. Valerenic acid also appears to inhibit the enzyme system responsible for the central catabolism of GABA, increasing GABA concentration and decreasing CNS activities. Valerian extracts containing amino acids and valerenic acid bind with the GABA-A receptor. In the brain cortex. Extract of Valerian inhibits the uptake and stimulates the release of GABA, leading to increase concentration of GABA in synaptic clefts. Valerenic acid may increasing inhibit enzymes that break down GABA, thus GABA levels and producing CNS-depressing effect.
মাত্রা ও সেবনবিধি
1 or 2 vegetable capsules daily, or as per the instruction of a registered physician.
প্রতিনির্দেশনা
The World Health Organization (WHO) contraindicates the use of Valerian for children under 12 years without medical supervision.
পার্শ্ব প্রতিক্রিয়া
Drowsiness Nausea Vomiting Stomach pain Heartburn Diarrhea Loss of interest in sex
গর্ভাবস্থায় ও স্তন্যদানকালে
The use of 5HTP in pregnancy or lactation has not been determined in controlled trials; therefore, it should not be used during pregnancy.
সতর্কতা
থেরাপিউটিক ক্লাস
Herbal and Nutraceuticals