Indications

Lansoprazole is indicated for: Short term treatment of active duodenal ulcer Maintenance of healed duodenal ulcers Short term treatment of active benign gastric ulcers Short term treatment of active erosive esophagitis Maintenance of healing of erosive esophagitis Pathological hypersecretory conditions including Zollinger-Ellison Syndrome H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Composition

Pharmacology

Lansoprazole is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H + /K + ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

Dosage & Administration

Benign gastric ulcer : 30 mg daily in the morning for 8 weeks. Duodenal ulcer : 30 mg daily in the morning for 4 weeks; maintenance 15 mg. NSAID-associated duodenal or gastric ulcer : 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed. Zollinger-Ellison syndrome (and other hypersecretory conditions) : Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses. Gastroesophageal reflux disease : 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily. Acid-related dyspepsia : 15-30 mg daily in the morning for 2-4 weeks.

Contraindications

Lansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects

Severe or irreversible adverse effects : The possible induction of carcinoid tumors by profound acid suppression, and a rise in serum gastrin may occur. There is a rise in serum gastrin levels in the first 3 months of treatment, which are then maintained though at a lower level than those found in pernicious anaemia. Long term treatment with a proton pump inhibitor in patients with Helicobacter pylori infection may accelerate the development of atrophic gastritis. Symptomatic adverse effect : Dose dependent diarrhoea occurs with an incidence of about 4% at 30 mg per day, rising to 8% at 60 mg per day. Headache occurs in 2-3% of treated patients

Pregnancy & Lactation

Lansoprazole should be avoided in pregnancy unless there are compelling reasons.

Precautions & Warnings

Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Store at 25° C.