Indications

Adapalene cream or gel is indicated for topical treatment of acne vulgaris.

Composition

Pharmacology

Adapalene acts on retinoid receptors that are commonly found in the skin of face, back and chest. Biochemical and pharmacological studies have demonstrated that Adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of that represent important features in the pathology of acne vulgaris. Adapalene binds with specific retinoic acid nuclear receptors that normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Absorption of Adapalene through human skin is low.

Dosage & Administration

Adapalene 0.1% : It should be applied to the affected areas of skin, once daily at night-time. Adapalene 0.3% : It should be applied to the entire face and any other affected areas of the skin, once daily in the evening. Children below 12 years of age : Safety and effectiveness in children below 12 years of age have not been established.

Contraindications

Adapalene should not be administered to individuals who are hypersensitive to Adapalene or any of its components.

Side Effects

Erythema, scaling, dryness, pruritus, burning sensation, skin irritation, stinging unburn, acne flares, etc. are commonly seen during the first month of therapy but usually lessen with continued use of the medication.

Pregnancy & Lactation

Use Adapalene during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in breast milk. Exercise caution when administering Adapalene to a nursing mother.

Precautions & Warnings

Adapalene should not be applied to cuts, abrasions, eczematous or sunburned skin.

Therapeutic Class

Topical retinoid and related preparations

Storage Conditions

Store in a cool (below 25°C) and dry place protected from light and moisture. Keep out of the reach of children. Keep the tube tightly closed after use.