Indications
Diloxanide is indicated for intestinal amoebiasis
Composition
Pharmacology
Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.
Dosage & Administration
Adult : The recommended dose is 500 mg 3 times/day for 10 days. May repeat course if needed. Child: >25 kg : 20 mg/kg daily in 3 divided doses for 10 days, repeated if necessary.
Contraindications
Hypersensitivity.
Side Effects
The frequency of these side-effects is unknown flatulence, itching, urticaria, vomiting
Pregnancy & Lactation
Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.
Precautions & Warnings
Caution should be exercised in pregnant and breastfeeding women. Avoid excess dosage.
Therapeutic Class
Amoebicides