Indications

This sterile eye drops is indicated for the treatment of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta blockers.

Composition

Pharmacology

Dorzolamide Hydrochloride and Timolol Maleate reduce intraocular pressure (IOP) by combined action. Dorzolamide is human carbonic anhydrase II inhibitor which decreases aqueous humor secretion by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol is a non-selective beta adrenergic receptor blocker that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane stabilizing) activity. It lowers IOP by decreasing the formation of aqueous humor in the ciliary epithelium.

Dosage & Administration

Instill one drop in the conjunctival sac of the affected eye(s) twice daily. Use in children : Safety and effectiveness in children below the age of 2 years have not been established. U se in elderly patients : No overall differences in safety and effectiveness have been observed between elderly and other adult patients.

Contraindications

Contraindicated in patients who are hypersensitive to any of the components of this preparation.

Side Effects

Mild burning, ocular hyperemia, blurred vision may occur.

Pregnancy & Lactation

Use in pregnancy : There are no adequate and well-controlled studies in pregnant women. This Eye Drops should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use in lactation : Caution should be exercised when This Eye Drops is administered to a nursing mother.

Precautions & Warnings

For ophthalmic use only. Patients should remove their contact lenses prior to instilling this preparation and should not insert their lenses until 15 minutes after instillation of the preparation.

Therapeutic Class

Drugs for miotics and glaucoma

Storage Conditions

Store in a cool & dry place, protect from light. Do not use longer than one month after first opening. Keep out of the reach of children.