নির্দেশনা
Tobramycin nebuliser solution is indicated for the management of cystic fibrosis in patients with Pseudomonas aeruginosa. Safety & efficacy have not been demonstrated in patients below the age of 6 years, patients with a forced expiratory volume <25% or >75% predicted, or patients colonized with Burkholderia cepacia.
Composition
ফার্মাকোলজি
Tobramycin nebuliser solution is a sterile, clear, slightly yellow, non-pyrogenic, aqueous sloution with the pH and salinity adjusted specifically for the administration by a nebuliser. Tobramycin is an aminoglycoside antibiotic and acts primarily by disrupting protein synthesis, leading to alter cell membrane permeability & eventual cell death. It is bactericidal & active against wide range of gram negative organisms including Pseudomonas aeruginosa.
মাত্রা ও সেবনবিধি
The 300 mg dose of Tobramycin is same for all patients regardless of age or weight (Tobramycin has not been studied in patients less than 6 years old). The recommended dose is one single-use ampoule (300 mg) to be inhaled b.i.d for 28 days. The dose should be taken as close to 12 hours apart as possible; they should not be taken less than 6 hours apart. If patient is taking several medications, the recommended order is as follows: bronchodilator first, followed by chest physiotherapy, then other inhaled medications & finally Tobramycin. Patient should take Tobramycin in repeated cycles of 28 days on drug, followed by 28 days off drug.
প্রতিনির্দেশনা
Tobramycin is contraindicated in patients with a known hypersensitivity to any aminoglycoside. Tobramycin nebuliser solution must only be used by inhalation from a nebuliser and must not be injected or swallowed.
পার্শ্ব প্রতিক্রিয়া
Inhaled Tobramycin is generally well-tolerated. Voice alterations and tinnitus are more common in the on-drug periods. However all the episodes are transient and resolved without discontinuation of the regimen. Others like dizziness and increase in serum creatinine were similar to those occurring with placebo.
গর্ভাবস্থায় ও স্তন্যদানকালে
Pregnancy category D. It is not recommended during pregnancy & lactation.
সতর্কতা
It should be used with care in patients with known or suspected renal, auditory, vestibular or neuromuscular dysfunction. Patients receiving concomitant aminoglycoside therapy should be monitored as clinically appropriate. Following complications may occur with Tobramycin: ototoxicity, muscular disorders, bronchospasm and nephrotoxicity.
থেরাপিউটিক ক্লাস
Aminoglycosides